From Troy to Ithaca:
The Odyssey by Homer
From Afghanistan to the United States:
The Kite Runner by Khaled Hosseini
From the United States to Guatemala:
Wanderlove by Kirsten Hubbard
From the United States to the Belgian Congo:
The Poisonwood Bible by Barbara Kingsolver
From England to India:
The Lost Girl by Sangu Mandanna
From the United States to France:
Anna and the French Kiss by Stephanie Perkins
Down the Mississippi River:
The Adventures of Huckleberry Finn by Mark Twain
...And that's all I can come up with that I recommend. I tried to stick to real locations here (except for The Odyssey, but it did kind of originate the whole travel book genre). Courtney and I were actually discussing this topic yesterday and we both came to the conclusion that while we read tons of fantasies that involve journeys and travel (my favorite fantasies are epic fantasies after all), we're woefully underread in books featuring real-world travels.
Please leave me links to your Top Ten Tuesdays - I'll be interested to see what sort of books featuring travel that I should be reading!